Molecular reproductive physiology

Decoding fertility.
Advancing agriculture.

We investigate the cellular and molecular mechanisms that shape livestock sire fertility—turning single-cell insight into tools for a more productive, sustainable future.

Blue sperm cell analyzed by diagonal single-cell phenomics sensors
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From a single cell
to a healthier herd.

At the intersection of biology, data, and animal agriculture, we’re building a clearer picture of male fertility—one cell at a time.

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Research

Four integrated programs move from molecular discovery to precision diagnostics.

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Publications

Peer-reviewed scholarship with corresponding- and first-author work emphasized.

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Research exchange

Invited talks, abstracts, posters, scientific meetings, and international instruction.

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Teaching

Anatomy, physiology, entrepreneurship, AI-enabled learning, and mentorship.

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Our research

Questions that move
the field forward.

Our multi-omic approach connects molecular signatures with reproductive outcomes in boars, bulls, and other sires.

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Multi-omics

Proteomics, lipidomics, metabolomics, genomics, and epigenomics reveal the systems behind reproductive success.

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Single-cell phenomics

High-throughput cellular imaging paired with artificial intelligence identifies meaningful fertility biomarkers.

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Translational andrology

Advanced assays turn discovery into practical insight for producers, breeders, and industry partners.

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Why it matters

More insight.
Fewer resources.
Stronger outcomes.

Improving our ability to predict and understand sire fertility can strengthen livestock efficiency while reducing the resources needed to produce food.

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Built for discovery

Technology that
makes cells visible.

Kerns Lab in vitro fertilization laboratory at Iowa State
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In vitro fertilization labTri-gas, time-lapse embryo imaging
Leica stereo microscopes with heated stages and cameras
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Imaging & instructionLeica stereo microscopes
Leica DMi8 inverted THUNDER microscope
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Embryo imagingLeica DMi8 THUNDER
Two ImageStreamX Mk II image-based flow cytometers
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Single-cell phenomicsImageStreamX Mk II systems
BD FACSMelody flow cytometer in the Kerns Lab
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Cell sortingBD FACSMelody
Leica DM6 THUNDER upright microscope
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Molecular imagingLeica DM6 THUNDER
Fluorescent microplate reader and Opentrons pipetting robot
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Lab automationPlate reader & pipetting robot
Mitochondrial Function Suite with Oroboros O2k systems
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Mitochondrial Function SuiteOroboros O2k systems
28,000cells per second captured by image-based flow cytometry
20×–60×objectives with brightfield, scatter, and fluorescence imaging
Tri-gastime-lapse in vitro embryo imaging capabilities

People & possibilities

Curious minds.
Shared purpose.

We are researchers, collaborators, and mentors committed to careful science and meaningful impact. Graduate students and collaborators are invited to start a conversation.

Meet the team
Tomorrow’s discoveries are being unearthed today.
— Kerns Lab

From the lab

Science, people, and momentum.

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Kerns Lab members together at SSR 2026Scientific meetings

Latest abstracts from the Kerns Lab

Karl Kerns in a black laboratory coatRecognition

Early Achievement in Research Award